Magnetic Resonance Multi-view Inverse Imaging (MV InI) for Human Brain

Dynamic MRI usually uses echo-planar imaging (EPI) [1] to achieve high temporal resolution. In brain imaging, modern MRI systems can achieve 3D spatial encoding with the whole-brain coverage using multi-slice EPI with TR of 2 s. A significant amount of time of multi-slice EPI is spent over k-space traversal. Recently, we proposed the MR inverse imaging (InI) [2] to achieve the unprecedented temporal resolution (100ms) with whole-brain coverage using simultaneous acquisitions from channels of an RF coil array. InI traded off the spatial resolution for temporal resolution in solving ill-posed inverse problem. In this study, we propose the multi-view inverse imaging (MV InI) to achieve fast 3D MR imaging without compromised spatial resolution. Specifically, MV InI acquires projection data from three orthogonal directions (x-, y-, and z-axes) and all channels of an RF coil array. All data are used simultaneously to solve the unknown 3D distribution of the magnetization. Here we present the pulse sequence and preliminary reconstruction of MV InI using a 32-channel head coil array at 3T to achieve 300 ms temporal resolution and 4 mm isotropic spatial resolution.